Researcher · Evidence Profile

Harold A. Sackeim

Harold A. Sackeim appears on 11 studies of vagus nerve stimulation catalogued in our evidence database, with a focus on Depression.

11
Studies
1
Conditions
4
RCT / SR-MA
2
Stim. types

Conditions researched

Depression11

Evidence-tier mix

Randomised controlled trial4
Non-randomised trial1
Cohort / observational6

The studies

11 studies · strongest evidence first

  1. Vagus nerve stimulation in treatment-resistant depression: A one-year, randomized, sham-controlled trial

    Conway et al. · Brain stimulation · 2025

    RCTsDepressiontaVNS
    Read summary & citations →DOI

  2. Effects of vagus nerve stimulation on daily function and quality of life in markedly treatment-resistant major depression: Findings from a one-year, randomized, sham-controlled trial

    Rush et al. · Brain stimulation · 2025

    RCTsDepressiontaVNS
    Read summary & citations →DOI

  3. A prospective, multi-center randomized, controlled, blinded trial of vagus nerve stimulation for difficult to treat depression: A novel design for a novel treatment

    Conway et al. · Contemporary clinical trials · 2020

    RCTsDepressioniVNS
    Read summary & citations →DOI

  4. Vagus nerve stimulation for treatment-resistant depression: a randomized, controlled acute phase trial

    Rush et al. · Biological Psychiatry · 2005 · n = 235

    RCTsDepressioniVNS
    Read summary & citations →DOI

  5. Vagus nerve stimulation (VNS) for treatment-resistant depressions: a multicenter study

    Rush et al. · Biological psychiatry · 2000 · n = 30

    controlled trialsDepressioniVNS
    Read summary & citations →DOI

  6. Durability of the benefit of vagus nerve stimulation in markedly treatment-resistant major depression: a RECOVER trial report

    Conway et al. · The international journal of neuropsychopharmacology · 2026 · n = 493

    observational studiesDepressioniVNS
    Read summary & citations →DOI

  7. Prognostic and Prescriptive Predictors of Treatment Response to Adjunctive VNS Therapy in Major Depressive Disorder: A RECOVER Trial Report

    Aaronson et al. · The Journal of Clinical Psychiatry · 2025 · n = 493

    observational studiesDepressioniVNS
    Read summary & citations →DOI

  8. A one-year comparison of vagus nerve stimulation with treatment as usual for treatment-resistant depression

    George et al. · Biological psychiatry · 2005 · n = 329

    observational studiesDepressioniVNS
    Read summary & citations →DOI

  9. Effects of 12 months of vagus nerve stimulation in treatment-resistant depression: a naturalistic study

    Rush et al. · Biological psychiatry · 2005 · n = 205

    observational studiesDepressioniVNS
    Read summary & citations →DOI

  10. Two-year outcome of vagus nerve stimulation (VNS) for treatment of major depressive episodes

    Nahas et al. · The Journal of clinical psychiatry · 2005 · n = 59

    observational studiesDepressioniVNS
    Read summary & citations →DOI

  11. Vagus nerve stimulation (VNS) for major depressive episodes: one year outcomes

    Marangell et al. · Biological psychiatry · 2002 · n = 30

    observational studiesDepressioniVNS
    Read summary & citations →DOI
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