Vagus nerve stimulation for treatment-resistant depression: a randomized, controlled acute phase trial
Rush AJ, Marangell LB, Sackeim HA, George MS, Brannan SK, Davis SM, Howland R, Kling MA, Rittberg BR, Burke WJ, et al.
Biological Psychiatry · 2005
Key finding
In the pivotal 10-week acute phase trial, active VNS produced a 15.2% response rate versus 10.0% for sham in treatment-resistant depression; the primary endpoint did not reach statistical significance.
- Condition
- Depression
- Stimulation
- iVNS
- Evidence tier
- Randomised Controlled Trial
- Participants
- 235
Cite this study
Rush, A. J., Marangell, L. B., Sackeim, H. A., George, M. S., Brannan, S. K., Davis, S. M., Howland, R., Kling, M. A., Rittberg, B. R., Burke, W. J., Rapaport, M. H., Zajecka, J., Nierenberg, A. A., Husain, M. M., Ginsberg, D., & Cooke, R. G. (2005). Vagus nerve stimulation for treatment-resistant depression: a randomized, controlled acute phase trial. Biological Psychiatry, 58(5), 347-354. https://doi.org/10.1016/j.biopsych.2005.05.025
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Summary by Vagus Research. Always consult the primary source for the authoritative record.