Addiction8 min read
Vagus Nerve Stimulation and Addiction: Can VNS Help?
An exploration of the emerging research on vagus nerve stimulation as a potential tool for addressing addiction and substance use disorders.
Browse & Search
Research Library
Explore our collection of evidence-based articles on vagus nerve stimulation, covering mechanisms, clinical applications, and the latest research findings.
Heart Failure10 min read
Vagus Nerve Stimulation for Heart Failure: What Clinical Trials Show
A review of the clinical trial evidence for vagus nerve stimulation in heart failure, including the landmark ANTHEM-HF and INOVATE-HF studies.
Parkinson's Disease9 min read
Vagus Nerve Stimulation for Parkinson's Disease: Emerging Evidence
An overview of the emerging research on vagus nerve stimulation as a potential therapeutic approach for Parkinson's disease.
Migraine15 min read
Vagus Nerve Stimulation for Migraine: From Trigeminal Pathways to Clinical Evidence
A comprehensive review of vagus nerve stimulation for migraine — covering clinical trial evidence, mechanisms involving trigeminal-vagal pathways and cortical spreading depression, and comparison with current therapies.
PTSD16 min read
Vagus Nerve Stimulation for PTSD: From Fear Circuits to Clinical Breakthroughs
An in-depth review of how vagus nerve stimulation targets the neural circuits underlying PTSD — from preclinical breakthroughs in fear extinction to landmark clinical trials showing complete loss of diagnosis.
Stroke15 min read
Vagus Nerve Stimulation for Stroke Rehabilitation: Targeted Plasticity Therapy
How VNS paired with rehabilitation drives targeted neuroplasticity to restore motor function after stroke — from the preclinical science at UT Dallas to FDA approval and long-term outcomes.
Tinnitus14 min read
Vagus Nerve Stimulation for Tinnitus: Reversing the Brain's Phantom Sound
How VNS paired with sound therapy targets the maladaptive auditory cortex reorganisation that generates tinnitus — from the landmark Nature study to emerging non-invasive approaches.
Cognitive Function11 min read
Vagus Nerve Stimulation and Cognitive Function: Can VNS Enhance the Mind?
Exploring the evidence that vagus nerve stimulation may enhance memory, attention, and cognitive performance through noradrenergic modulation.
Heart Health11 min read
Vagus Nerve Stimulation and Heart Rate Variability: The Autonomic Connection
How vagus nerve stimulation influences heart rate variability — a key biomarker of autonomic health — and what this means for clinical applications.
Neuroplasticity12 min read
Vagus Nerve Stimulation and Neuroplasticity: Rewiring the Brain
How vagus nerve stimulation promotes neural plasticity — from BDNF expression to stroke rehabilitation to enhanced learning.
Pain12 min read
Vagus Nerve Stimulation for Pain: What the Research Shows
A review of the evidence for vagus nerve stimulation in pain management — from migraine to fibromyalgia to chronic pain conditions.
Depression14 min read
Vagus Nerve Stimulation for Depression: What the Evidence Shows
A comprehensive review of how vagus nerve stimulation — both implanted and transcutaneous — is being investigated as a treatment for major depressive disorder.
Sleep12 min read
Vagus Nerve Stimulation and Sleep: Can VNS Improve Sleep Quality?
A review of the growing evidence that vagus nerve stimulation may improve sleep quality by modulating autonomic balance and brain networks involved in the sleep–wake cycle.
Foundation12 min read
What Is Vagus Nerve Stimulation? A Complete Guide
A comprehensive overview of vagus nerve stimulation — what it is, how it works, and what the research shows.
Inflammation13 min read
Vagus Nerve Stimulation and Inflammation: The Cholinergic Anti-Inflammatory Pathway
How vagus nerve stimulation activates the body's built-in anti-inflammatory circuit — and what clinical trials show about its potential for inflammatory conditions.
Gut Health11 min read
Vagus Nerve Stimulation and Gut Health: The Gut–Brain Axis
How the vagus nerve connects the gut and brain, and what the evidence shows about VNS for gastrointestinal conditions including Crohn's disease and IBS.
Safety10 min read
Is Vagus Nerve Stimulation Safe? What 177 Studies Tell Us
A detailed analysis of the safety profile of vagus nerve stimulation across 177 peer-reviewed studies.
Epilepsy13 min read
Vagus Nerve Stimulation for Epilepsy: The Original Application
Epilepsy was the first condition treated with VNS and remains the most established application. Here's what three decades of evidence show.
Anxiety11 min read
Vagus Nerve Stimulation for Anxiety: What the Research Shows
An evidence-based review of how vagus nerve stimulation may help manage anxiety through autonomic regulation.