Long-term efficacy and safety of vagus nerve stimulation in treatment-resistant depression: A systematic review
Rosson S, Bresolin N, D'Amico A, Denaro L, Landi A, Sambataro F, Pigato G
Journal of Affective Disorders · 2026
Key finding
PRISMA systematic review of 10 cohort studies and 8 case series (>900 cases) found adjunctive VNS provided sustained response and remission over 2 or more years in treatment-resistant depression.
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- Condition
- Depression
- Stimulation
- iVNS
- Evidence tier
- Systematic Review / Meta-Analysis
- Participants
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Cite this study
Rosson, S., Bresolin, N., D'Amico, A., Denaro, L., Landi, A., Sambataro, F., & Pigato, G. (2026). Long-term efficacy and safety of vagus nerve stimulation in treatment-resistant depression: A systematic review. Journal of Affective Disorders, 394, 120483. https://doi.org/10.1016/j.jad.2025.120483
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