Two-year outcome of vagus nerve stimulation (VNS) for treatment of major depressive episodes
Nahas Z, Marangell LB, Husain MM, Rush AJ, Sackeim HA, Lisanby SH, Martinez JM, George MS
The Journal of Clinical Psychiatry · 2005
Key finding
In 59 patients, response rates were 31% at 3 months, 44% at 1 year and 42% at 2 years, indicating benefit sustained over 24 months.
Auto-extracted · verification pendingHow we verify
- Condition
- Depression
- Stimulation
- iVNS
- Evidence tier
- Observational / Cohort
- Participants
- 59
Share this study
Download the citation card as a PNG, or copy a link to this page.
Cite this study
Nahas, Z., Marangell, L. B., Husain, M. M., Rush, A. J., Sackeim, H. A., Lisanby, S. H., Martinez, J. M., & George, M. S. (2005). Two-year outcome of vagus nerve stimulation (VNS) for treatment of major depressive episodes. The Journal of Clinical Psychiatry, 66(09), 1097-1104. https://doi.org/10.4088/jcp.v66n0902
Related studies in Depression
Long-term efficacy and safety of vagus nerve stimulation in treatment-resistant depression: A systematic review
Rosson et al. · Journal of Affective Disorders · 2026 · Systematic Review / Meta-Analysis
Transcutaneous Auricular Vagus Nerve Stimulation: Efficacy, Applications, and Challenges in Mood Disorders and Autonomic Regulation-A Narrative Review
Croft et al. · Military medicine · 2025 · Systematic Review / Meta-Analysis
The efficacy and safety of transcutaneous auricular vagus nerve stimulation in the treatment of depressive disorder: a systematic review and meta-analysis of randomized controlled trials
Tan et al. · Journal of Affective Disorders · 2023 · Systematic Review / Meta-Analysis
Adjunctive Vagus Nerve Stimulation for Treatment-Resistant Depression: a Quantitative Analysis
Zhang et al. · The Psychiatric quarterly · 2020 · Systematic Review / Meta-Analysis
Summary by Vagus Research. Always consult the primary source for the authoritative record.