Durability of the benefit of vagus nerve stimulation in markedly treatment-resistant major depression: a RECOVER trial report
Conway CR, Rush AJ, Aaronson ST, Bunker MT, Gordon C, George MS, Riva-Posse P, Allen RM, Nahas Z, Kriedt CL, et al.
International Journal of Neuropsychopharmacology · 2026
Key finding
Across 24-month RECOVER follow-up, about two-thirds of participants who reached meaningful benefit at 12 months sustained it at 24 months, with roughly one-third progressing to full response.
- Condition
- Depression
- Stimulation
- iVNS
- Evidence tier
- Observational / Cohort
- Participants
- 493
Cite this study
Conway, C. R., Rush, A. J., Aaronson, S. T., Bunker, M. T., Gordon, C., George, M. S., Riva-Posse, P., Allen, R. M., Nahas, Z., Kriedt, C. L., Zajecka, J., Dunner, D. L., Quevedo, J., Sheline, Y., Duffy, W., Mickey, B. J., Stedman, M., Alva, G., Manu, L., … Sackeim, H. A. (2026). Durability of the benefit of vagus nerve stimulation in markedly treatment-resistant major depression: a RECOVER trial report. International Journal of Neuropsychopharmacology, 29(1). https://doi.org/10.1093/ijnp/pyaf080
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Summary by Vagus Research. Always consult the primary source for the authoritative record.