Prognostic and Prescriptive Predictors of Treatment Response to Adjunctive VNS Therapy in Major Depressive Disorder: A RECOVER Trial Report
Aaronson ST, Conway CR, Gordon C, Lee YC(, George MS, Zajecka J, Riva-Posse P, Dunner DL, Macaluso M, Rosenquist PB, et al.
The Journal of Clinical Psychiatry · 2025
Key finding
Prior ECT/TMS exposure predicted especially poor outcomes on sham VNS, an effect active VNS appeared to mitigate, while absence of comorbid anxiety predicted greater active-VNS benefit.
- Condition
- Depression
- Stimulation
- iVNS
- Evidence tier
- Observational / Cohort
- Participants
- 493
Cite this study
Aaronson, S. T., Conway, C. R., Gordon, C., Lee, Y. C. (., George, M. S., Zajecka, J., Riva-Posse, P., Dunner, D. L., Macaluso, M., Rosenquist, P. B., Mickey, B. J., Sheline, Y. I., Hristidis, V. C., Brown, H., Kriedt, C. L., Tran, Q., Bunker, M. T., Sackeim, H. A., & Rush, A. J. (2025). Prognostic and Prescriptive Predictors of Treatment Response to Adjunctive VNS Therapy in Major Depressive Disorder: A RECOVER Trial Report. The Journal of Clinical Psychiatry, 86(3). https://doi.org/10.4088/jcp.25m15850
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Summary by Vagus Research. Always consult the primary source for the authoritative record.