Effect of transcutaneous auricular vagus nerve stimulation on major depressive disorder: a nonrandomized controlled pilot study
Rong P, Liu J, Wang L, Liu R, Fang J, Zhao J, Zhao Y, Wang H, Vangel M, Sun S, et al.
Journal of Affective Disorders · 2016
Key finding
Four weeks of taVNS significantly reduced Hamilton Depression Rating Scale scores compared to sham, with a response rate of 37.5% versus 12.5% in controls.
- Condition
- Depression
- Stimulation
- taVNS
- Evidence tier
- Controlled Clinical Trial
- Participants
- 160
Cite this study
Rong, P., Liu, J., Wang, L., Liu, R., Fang, J., Zhao, J., Zhao, Y., Wang, H., Vangel, M., Sun, S., Ben, H., Park, J., Li, S., Meng, H., Zhu, B., & Kong, J. (2016). Effect of transcutaneous auricular vagus nerve stimulation on major depressive disorder: a nonrandomized controlled pilot study. Journal of Affective Disorders, 195, 172-179. https://doi.org/10.1016/j.jad.2016.02.031
Related studies in Depression
Long-term efficacy and safety of vagus nerve stimulation in treatment-resistant depression: A systematic review
Rosson et al. · Journal of Affective Disorders · 2026 · Systematic Review / Meta-Analysis
The efficacy and safety of transcutaneous auricular vagus nerve stimulation in the treatment of depressive disorder: a systematic review and meta-analysis of randomized controlled trials
Tan et al. · Journal of Affective Disorders · 2023 · Systematic Review / Meta-Analysis
Adjunctive Vagus Nerve Stimulation for Treatment-Resistant Depression: a Quantitative Analysis
Zhang et al. · The Psychiatric quarterly · 2020 · Systematic Review / Meta-Analysis
Vagus Nerve Stimulation for Depression: A Systematic Review
Lv et al. · Frontiers in psychology · 2019 · Systematic Review / Meta-Analysis
Summary by Vagus Research. Always consult the primary source for the authoritative record.