Baseline functional connectivity of the basal forebrain-cortical circuit predict taVNS treatment response in primary insomnia: a randomized controlled trial and fMRI study
Qi M, Huang Y, Mai R, Yan Z, Xu B, Liu B, Zhang Y
BMC Medicine · 2025
Key finding
In an RCT of 70 adults with primary insomnia, taVNS reduced insomnia-severity, sleep-quality and anxiety scores versus sham; baseline basal-forebrain connectivity predicted response.
Auto-extracted · verification pendingHow we verify
- Condition
- Sleep
- Stimulation
- taVNS
- Evidence tier
- Randomised Controlled Trial
- Participants
- 70
Share this study
Download the citation card as a PNG, or copy a link to this page.
Cite this study
Qi, M., Huang, Y., Mai, R., Yan, Z., Xu, B., Liu, B., & Zhang, Y. (2025). Baseline functional connectivity of the basal forebrain-cortical circuit predict taVNS treatment response in primary insomnia: a randomized controlled trial and fMRI study. BMC Medicine, 23(1). https://doi.org/10.1186/s12916-025-04126-7
Related studies in Sleep
Transcutaneous auricular vagus nerve stimulation in insomnia: a systematic review and meta-analysis
De Oliveira et al. · Neuromodulation · 2025 · Systematic Review / Meta-Analysis
The Effect of Transcutaneous Auricular Vagus Nerve Stimulation on Sleep Quality in Insomnia: a Systematic Review and Meta-analysis
Hasani et al. · Current Sleep Medicine Reports · 2025 · Systematic Review / Meta-Analysis
Brain stimulation techniques as novel treatment options for insomnia: A systematic review
Krone et al. · Journal of sleep research · 2023 · Systematic Review / Meta-Analysis
Transcutaneous auricular vagus nerve stimulation to treat narcolepsy type 1 (TARGET-NT1): A two-arm, randomised, sham-controlled trial
Pan et al. · Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025 · Randomised Controlled Trial
Summary by Vagus Research. Always consult the primary source for the authoritative record.