Transcutaneous auricular vagus nerve stimulation in insomnia: a systematic review and meta-analysis
de Oliveira HM, Gallo Ruelas M, Viana Diaz CA, Oliveira de Paula G, Fruett da Costa PR, Pilitsis JG
Neuromodulation: Technology at the Neural Interface · 2025
Key finding
Pooling data from six studies, taVNS significantly improved PSQI scores (MD = -3.60) and Insomnia Severity Index scores (MD = -5.24), with improvements across multiple sleep dimensions and minimal adverse effects.
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- Condition
- Sleep
- Stimulation
- taVNS
- Evidence tier
- Systematic Review / Meta-Analysis
- Participants
- 336
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Cite this study
de Oliveira, H. M., Gallo Ruelas, M., Viana Diaz, C. A., Oliveira de Paula, G., Fruett da Costa, P. R., & Pilitsis, J. G. (2025). Transcutaneous auricular vagus nerve stimulation in insomnia: a systematic review and meta-analysis. Neuromodulation: Technology at the Neural Interface, 28(8), 1332-1340. https://doi.org/10.1016/j.neurom.2025.04.001
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