Potential of Vagus Nerve Stimulation to Modulate Fibromyalgia's Network Physiology: A Systematic Review
Perin JP, Pastora-Sesín C, Kang S, Navarro-Flores A, Fregni F, Pacheco-Barrios K
Journal of Functional Morphology and Kinesiology · 2025
Key finding
Conclusions: By reframing FMS from a symptom-centric pharmacologic model to a network-centric neuromodulation approach, taVNS is a promising tool for mechanism-based therapeutics in central sensitization syndromes and chronic pain.
- Condition
- Fibromyalgia
- Stimulation
- taVNS
- Evidence tier
- Systematic Review / Meta-Analysis
- Participants
- —
Cite this study
Perin, J. P., Pastora-Sesín, C., Kang, S., Navarro-Flores, A., Fregni, F., & Pacheco-Barrios, K. (2025). Potential of Vagus Nerve Stimulation to Modulate Fibromyalgia's Network Physiology: A Systematic Review. Journal of Functional Morphology and Kinesiology, 11(1), 15. https://doi.org/10.3390/jfmk11010015
Related studies in Fibromyalgia
Evaluating the efficacy and acceptability of vagus nerve stimulation for fibromyalgia: a PRISMA-compliant protocol for a systematic review and meta-analysis
Cai et al. · Frontiers in neurology · 2024 · Systematic Review / Meta-Analysis
Laterality-Dependent Biological Effects of Manual Acupuncture Stimulation of the Auricular Vagus Nerve in Women with Fibromyalgia: A Randomized, Sham-Controlled Trial
Neves et al. · Pain medicine (Malden, Mass.) · 2026 · Randomised Controlled Trial
Effects of left and bilateral transcutaneous auricular vagus nerve stimulation on pain, mood, and autonomic nervous system in female patients with fibromyalgia: a randomized controlled trial
Akkurt et al. · Physiotherapy theory and practice · 2025 · Randomised Controlled Trial
Meditative-based diaphragmatic breathing vs. vagus nerve stimulation in the treatment of fibromyalgia-A randomized controlled trial: Body vs. machine
Paccione et al. · Frontiers in neurology · 2022 · Randomised Controlled Trial
Summary by Vagus Research. Always consult the primary source for the authoritative record.