Laterality-Dependent Biological Effects of Manual Acupuncture Stimulation of the Auricular Vagus Nerve in Women with Fibromyalgia: A Randomized, Sham-Controlled Trial
Neves ML, Coutinho BD, Speretta GFF, Kraus SI, Ferreira JB, Amaral PAH, Bud JEDS, Da Silva AM, Wippel VA, Rodrigues IK, et al.
Pain Medicine · 2026
Key finding
While no significant between-group differences were observed in pain intensity, left-sided stimulation (aVNS-L) was associated with a modest but significant reduction in global symptom severity.
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- Condition
- Fibromyalgia
- Stimulation
- taVNS
- Evidence tier
- Randomised Controlled Trial
- Participants
- —
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Cite this study
Neves, M. L., Coutinho, B. D., Speretta, G. F. F., Kraus, S. I., Ferreira, J. B., Amaral, P. A. H., Bud, J. E. D. S., Da Silva, A. M., Wippel, V. A., Rodrigues, I. K., Duarte, M. M. M. F., Ilha, J., & da Silva, M. D. (2026). Laterality-Dependent Biological Effects of Manual Acupuncture Stimulation of the Auricular Vagus Nerve in Women with Fibromyalgia: A Randomized, Sham-Controlled Trial. Pain Medicine, 27(7), 804-813. https://doi.org/10.1093/pm/pnag013
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