Transvenous vagus nerve stimulation does not modulate the innate immune response during experimental human endotoxemia: a randomized controlled study
Kox M, van Eijk LT, Verhaak T, Frenzel T, Kiers HD, Gerretsen J, van der Hoeven JG, Kornet L, Scheiner A, Pickkers P
Arthritis Research & Therapy · 2015
Key finding
In healthy men given LPS, transvenous VNS was feasible and safe but did not modulate the endotoxemia-induced cytokine response (null result).
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- Condition
- Inflammation
- Stimulation
- iVNS
- Evidence tier
- Randomised Controlled Trial
- Participants
- 20
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Cite this study
Kox, M., van Eijk, L. T., Verhaak, T., Frenzel, T., Kiers, H. D., Gerretsen, J., van der Hoeven, J. G., Kornet, L., Scheiner, A., & Pickkers, P. (2015). Transvenous vagus nerve stimulation does not modulate the innate immune response during experimental human endotoxemia: a randomized controlled study. Arthritis Research & Therapy, 17(1). https://doi.org/10.1186/s13075-015-0667-5
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