Effect of transcutaneous auricular vagus nerve stimulation on major depressive disorder with peripartum onset: A multicenter, open-label, controlled proof-of-concept clinical trial (DELOS-1)
Deligiannidis KM, Robakis T, Homitsky SC, Ibroci E, King B, Jacob S, Coppola D, Raines S, Alataris K
Journal of Affective Disorders · 2022
Key finding
In 25 women with peripartum-onset MDD, 6 weeks of open-label taVNS yielded 74% response and 61% remission with a mean HAM-D reduction of ~9.7 points and no serious adverse events.
- Condition
- Depression
- Stimulation
- taVNS
- Evidence tier
- Controlled Clinical Trial
- Participants
- 25
Cite this study
Deligiannidis, K. M., Robakis, T., Homitsky, S. C., Ibroci, E., King, B., Jacob, S., Coppola, D., Raines, S., & Alataris, K. (2022). Effect of transcutaneous auricular vagus nerve stimulation on major depressive disorder with peripartum onset: A multicenter, open-label, controlled proof-of-concept clinical trial (DELOS-1). Journal of Affective Disorders, 316, 34-41. https://doi.org/10.1016/j.jad.2022.07.068
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Summary by Vagus Research. Always consult the primary source for the authoritative record.