A prospective, multi-center randomized, controlled, blinded trial of vagus nerve stimulation for difficult to treat depression: A novel design for a novel treatment
Conway CR, Olin B, Aaronson ST, Sackeim HA, Bunker M, Kriedt C, Greco T, Broglio K, Vestrucci M, Rush AJ
Contemporary Clinical Trials · 2020
Key finding
This RCT is unique for DTD studies: 1) large sample size and long study duration (one year of controlled comparison); 2) use of a percent time in response as the primary outcome measure, given the chronic illness and its fluctuating course (vis-à-vis meeting a response criteria at a single time p...
- Condition
- Depression
- Stimulation
- iVNS
- Evidence tier
- Randomised Controlled Trial
- Participants
- —
Cite this study
Conway, C. R., Olin, B., Aaronson, S. T., Sackeim, H. A., Bunker, M., Kriedt, C., Greco, T., Broglio, K., Vestrucci, M., & Rush, A. J. (2020). A prospective, multi-center randomized, controlled, blinded trial of vagus nerve stimulation for difficult to treat depression: A novel design for a novel treatment. Contemporary Clinical Trials, 95, 106066. https://doi.org/10.1016/j.cct.2020.106066
Related studies in Depression
Long-term efficacy and safety of vagus nerve stimulation in treatment-resistant depression: A systematic review
Rosson et al. · Journal of Affective Disorders · 2026 · Systematic Review / Meta-Analysis
The efficacy and safety of transcutaneous auricular vagus nerve stimulation in the treatment of depressive disorder: a systematic review and meta-analysis of randomized controlled trials
Tan et al. · Journal of Affective Disorders · 2023 · Systematic Review / Meta-Analysis
Adjunctive Vagus Nerve Stimulation for Treatment-Resistant Depression: a Quantitative Analysis
Zhang et al. · The Psychiatric quarterly · 2020 · Systematic Review / Meta-Analysis
Vagus Nerve Stimulation for Depression: A Systematic Review
Lv et al. · Frontiers in psychology · 2019 · Systematic Review / Meta-Analysis
Summary by Vagus Research. Always consult the primary source for the authoritative record.