Vagus nerve stimulation (VNS) therapy in patients with treatment resistant depression: A systematic review and meta-analysis
Bottomley JM, LeReun C, Diamantopoulos A, Mitchell S, Gaynes BN
Comprehensive Psychiatry · 2019
Key finding
A systematic review and meta-analysis of 22 studies (2 RCTs, 16 single-arm, 4 non-randomised) of VNS for treatment-resistant depression, pooling depression, safety and quality-of-life outcomes; most included evidence is uncontrolled.
Auto-extracted · verification pendingHow we verify
- Condition
- Depression
- Stimulation
- iVNS
- Evidence tier
- Systematic Review / Meta-Analysis
- Participants
- —
Share this study
Download the citation card as a PNG, or copy a link to this page.
Cite this study
Bottomley, J. M., LeReun, C., Diamantopoulos, A., Mitchell, S., & Gaynes, B. N. (2019). Vagus nerve stimulation (VNS) therapy in patients with treatment resistant depression: A systematic review and meta-analysis. Comprehensive Psychiatry, 98, 152156. https://doi.org/10.1016/j.comppsych.2019.152156
Related studies in Depression
Long-term efficacy and safety of vagus nerve stimulation in treatment-resistant depression: A systematic review
Rosson et al. · Journal of Affective Disorders · 2026 · Systematic Review / Meta-Analysis
Transcutaneous Auricular Vagus Nerve Stimulation: Efficacy, Applications, and Challenges in Mood Disorders and Autonomic Regulation-A Narrative Review
Croft et al. · Military medicine · 2025 · Systematic Review / Meta-Analysis
The efficacy and safety of transcutaneous auricular vagus nerve stimulation in the treatment of depressive disorder: a systematic review and meta-analysis of randomized controlled trials
Tan et al. · Journal of Affective Disorders · 2023 · Systematic Review / Meta-Analysis
Adjunctive Vagus Nerve Stimulation for Treatment-Resistant Depression: a Quantitative Analysis
Zhang et al. · The Psychiatric quarterly · 2020 · Systematic Review / Meta-Analysis
Summary by Vagus Research. Always consult the primary source for the authoritative record.