Vagus Nerve Stimulation Therapy Randomized to Different Amounts of Electrical Charge for Treatment-Resistant Depression: Acute and Chronic Effects
Aaronson ST, Carpenter LL, Conway CR, Reimherr FW, Lisanby SH, Schwartz TL, Moreno FA, Dunner DL, Lesem MD, Thompson PM, et al.
Brain Stimulation · 2013
Key finding
Higher electrical-charge VNS doses produced significantly greater durability of antidepressant response than the low dose, with no acute-phase difference between dose groups.
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- Condition
- Depression
- Stimulation
- iVNS
- Evidence tier
- Randomised Controlled Trial
- Participants
- 331
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Cite this study
Aaronson, S. T., Carpenter, L. L., Conway, C. R., Reimherr, F. W., Lisanby, S. H., Schwartz, T. L., Moreno, F. A., Dunner, D. L., Lesem, M. D., Thompson, P. M., Husain, M., Vine, C. J., Banov, M. D., Bernstein, L. P., Lehman, R. B., Brannon, G. E., Keepers, G. A., O'Reardon, J. P., Rudolph, R. L., & Bunker, M. (2013). Vagus Nerve Stimulation Therapy Randomized to Different Amounts of Electrical Charge for Treatment-Resistant Depression: Acute and Chronic Effects. Brain Stimulation, 6(4), 631-640. https://doi.org/10.1016/j.brs.2012.09.013
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