Chronic vagal stimulation for the treatment of low ejection fraction heart failure: results of the NEural Cardiac TherApy foR Heart Failure (NECTAR-HF) randomized controlled trial
Zannad F, De Ferrari GM, Tuinenburg AE, Wright D, Brugada J, Butter C, Klein H, Stolen C, Meyer S, Stein KM, et al.
European Heart Journal · 2015
Key finding
VNS did not significantly improve cardiac remodelling measures, but quality of life (MLHFQ, NYHA class, SF-36) improved significantly, suggesting patient-perceived benefits despite neutral primary endpoints.
Auto-extracted · verification pendingHow we verify
- Condition
- Heart Failure
- Stimulation
- iVNS
- Evidence tier
- Randomised Controlled Trial
- Participants
- 96
Share this study
Download the citation card as a PNG, or copy a link to this page.
Cite this study
Zannad, F., De Ferrari, G. M., Tuinenburg, A. E., Wright, D., Brugada, J., Butter, C., Klein, H., Stolen, C., Meyer, S., Stein, K. M., Ramuzat, A., Schubert, B., Daum, D., Neuzil, P., Botman, C., Castel, M. A., D'Onofrio, A., Solomon, S. D., Wold, N., & Ruble, S. B. (2015). Chronic vagal stimulation for the treatment of low ejection fraction heart failure: results of the NEural Cardiac TherApy foR Heart Failure (NECTAR-HF) randomized controlled trial. European Heart Journal, 36(7), 425-433. https://doi.org/10.1093/eurheartj/ehu345
Related studies in Heart Failure
Network meta-analysis on efficacy of nerve stimulation or modulation in patients with heart failure
Tseng et al. · Heart rhythm · 2026 · Systematic Review / Meta-Analysis
The efficacy of transcutaneous vagus nerve stimulation in heart failure management - a systematic review and meta-analysis
Sun et al. · BMC cardiovascular disorders · 2025 · Systematic Review / Meta-Analysis
Non-pharmacologic autonomic neuromodulation for treatment of heart failure: A systematic review and meta-analysis of randomized controlled trials
Ahmed et al. · Trends in cardiovascular medicine · 2024 · Systematic Review / Meta-Analysis
Vagal Neuromodulation in Chronic Heart Failure With Reduced Ejection Fraction: A Systematic Review and Meta-Analysis
Sant'Anna et al. · Frontiers in Cardiovascular Medicine · 2021 · Systematic Review / Meta-Analysis
Summary by Vagus Research. Always consult the primary source for the authoritative record.