Chronic vagal stimulation for the treatment of low ejection fraction heart failure: results of the NEural Cardiac TherApy foR Heart Failure (NECTAR-HF) randomized controlled trial
Zannad F, De Ferrari GM, Tuinenburg AE, Wright D, Brugada J, Butter C, Klein H, Stolen C, Meyer S, Stein KM, et al.
European Heart Journal · 2015
Key finding
VNS did not significantly improve cardiac remodelling measures, but quality of life (MLHFQ, NYHA class, SF-36) improved significantly, suggesting patient-perceived benefits despite neutral primary endpoints.
- Condition
- Heart Failure
- Stimulation
- iVNS
- Evidence tier
- Randomised Controlled Trial
- Participants
- 96
Cite this study
Zannad, F., De Ferrari, G. M., Tuinenburg, A. E., Wright, D., Brugada, J., Butter, C., Klein, H., Stolen, C., Meyer, S., Stein, K. M., Ramuzat, A., Schubert, B., Daum, D., Neuzil, P., Botman, C., Castel, M. A., D'Onofrio, A., Solomon, S. D., Wold, N., & Ruble, S. B. (2015). Chronic vagal stimulation for the treatment of low ejection fraction heart failure: results of the NEural Cardiac TherApy foR Heart Failure (NECTAR-HF) randomized controlled trial. European Heart Journal, 36(7), 425-433. https://doi.org/10.1093/eurheartj/ehu345
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Summary by Vagus Research. Always consult the primary source for the authoritative record.