Assessment of Noninvasive Brain Stimulation Interventions for Negative Symptoms of Schizophrenia: A Systematic Review and Network Meta-analysis
Tseng PT, Zeng BS, Hung CM, Liang CS, Stubbs B, Carvalho AF, Brunoni AR, Su KP, Tu YK, Wu YC, et al.
JAMA Psychiatry · 2022
Key finding
Forty-eight RCTs involving 2211 participants (mean [range] age, 38.7 [24.0-57.0] years; mean [range] proportion of female patients, 30.6% [0%-70.0%]) were included.
- Condition
- Schizophrenia
- Stimulation
- tcVNS
- Evidence tier
- Systematic Review / Meta-Analysis
- Participants
- 2,211
Cite this study
Tseng, P. T., Zeng, B. S., Hung, C. M., Liang, C. S., Stubbs, B., Carvalho, A. F., Brunoni, A. R., Su, K. P., Tu, Y. K., Wu, Y. C., Chen, T. Y., Li, D. J., Lin, P. Y., Hsu, C. W., Chen, Y. W., Suen, M. W., Satogami, K., Takahashi, S., Wu, C. K., … Li, C. T. (2022). Assessment of Noninvasive Brain Stimulation Interventions for Negative Symptoms of Schizophrenia: A Systematic Review and Network Meta-analysis. JAMA Psychiatry, 79(8), 770. https://doi.org/10.1001/jamapsychiatry.2022.1513
Related studies in Schizophrenia
Non-invasive brain stimulation for negative symptoms in schizophrenia: An updated systematic review and meta-analysis
Osoegawa et al. · Schizophrenia research · 2018 · Systematic Review / Meta-Analysis
Effect of transcutaneous auricular vagus nerve stimulation on the improvement of cognitive function in older patients with schizophrenia
Xiang et al. · General Psychiatry · 2026 · Randomised Controlled Trial
Efficacy and safety of transcutaneous auricular vagus nerve stimulation for patients with treatment-resistant schizophrenia with predominantly negative symptoms: a randomized clinical trial and efficacy sensitivity biomarkers
Cui et al. · Molecular psychiatry · 2025 · Randomised Controlled Trial
Treatment trials for negative symptoms in schizophrenia
Glenthøj et al. · Current opinion in psychiatry · 2025 · Randomised Controlled Trial
Summary by Vagus Research. Always consult the primary source for the authoritative record.