Efficacy and safety of transcutaneous auricular vagus nerve stimulation for patients with treatment-resistant schizophrenia with predominantly negative symptoms: a randomized clinical trial and efficacy sensitivity biomarkers
Cui Y, Sun J, Zhang B, Guo T, Zhang S, Li Z, Chen Y, Su M, Wu D, Wu J, et al.
Molecular Psychiatry · 2025
Key finding
In the intention-to-treat analysis, patients receiving active taVNS showed a significantly greater improvement in negative symptoms compared with those receiving the sham procedure (PANSS-FSNS difference, -1.36; effect size, -0.62; 95% CI, -1.20 to -0.04; p = 0.033), with effects sustained at fol...
- Condition
- Schizophrenia
- Stimulation
- taVNS
- Evidence tier
- Randomised Controlled Trial
- Participants
- 50
Cite this study
Cui, Y., Sun, J., Zhang, B., Guo, T., Zhang, S., Li, Z., Chen, Y., Su, M., Wu, D., Wu, J., Wang, Q., Yuan, Y., Wang, J., Tian, Q., He, F., Wu, L., Li, X., Gong, Y., & Qin, W. (2025). Efficacy and safety of transcutaneous auricular vagus nerve stimulation for patients with treatment-resistant schizophrenia with predominantly negative symptoms: a randomized clinical trial and efficacy sensitivity biomarkers. Molecular Psychiatry, 30(11), 5437-5447. https://doi.org/10.1038/s41380-025-03132-8
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Summary by Vagus Research. Always consult the primary source for the authoritative record.