Neuromodulation of Inflammation to Treat Heart Failure With Preserved Ejection Fraction: A Pilot Randomized Clinical Trial
Stavrakis S, Elkholey K, Morris L, Niewiadomska M, Asad ZUA, Humphrey MB
Journal of the American Heart Association · 2022
Key finding
While the early mitral inflow Doppler velocity to the early diastolic mitral annulus velocity ratio did not differ between groups, global longitudinal strain and tumor necrosis factor-α levels at 3 months were significantly improved in the active compared with the sham arm (-18.6%±2.5% versus -16...
- Condition
- Heart Failure
- Stimulation
- taVNS
- Evidence tier
- Randomised Controlled Trial
- Participants
- 26
Cite this study
Stavrakis, S., Elkholey, K., Morris, L., Niewiadomska, M., Asad, Z. U. A., & Humphrey, M. B. (2022). Neuromodulation of Inflammation to Treat Heart Failure With Preserved Ejection Fraction: A Pilot Randomized Clinical Trial. Journal of the American Heart Association, 11(3). https://doi.org/10.1161/JAHA.121.023582
Related studies in Heart Failure
Network meta-analysis on efficacy of nerve stimulation or modulation in patients with heart failure
Tseng et al. · Heart rhythm · 2026 · Systematic Review / Meta-Analysis
Complications of Implanted Vagus Nerve Stimulation: A Systematic Review and Meta-Analysis
Kalagara et al. · Cerebrovascular diseases (Basel, Switzerland) · 2025 · Systematic Review / Meta-Analysis
The efficacy of transcutaneous vagus nerve stimulation in heart failure management - a systematic review and meta-analysis
Sun et al. · BMC cardiovascular disorders · 2025 · Systematic Review / Meta-Analysis
Non-pharmacologic autonomic neuromodulation for treatment of heart failure: A systematic review and meta-analysis of randomized controlled trials
Ahmed et al. · Trends in cardiovascular medicine · 2024 · Systematic Review / Meta-Analysis
Summary by Vagus Research. Always consult the primary source for the authoritative record.