Long-term Follow-Up of Patients with Heart Failure and Reduced Ejection Fraction Receiving Autonomic Regulation Therapy in the ANTHEM-HF Pilot Study
Sharma K, Premchand RK, Mittal S, Monteiro R, Libbus I, DiCarlo LA, Ardell JL, Amurthur B, KenKnight BH, Anand IS
International Journal of Cardiology · 2021
Key finding
Long-term autonomic regulation therapy with vagus nerve stimulation remained well tolerated and was associated with sustained improvement in cardiac function and heart failure symptoms over multi-year follow-up.
- Condition
- Heart Failure
- Stimulation
- iVNS
- Evidence tier
- Observational / Cohort
- Participants
- 60
Cite this study
Sharma, K., Premchand, R. K., Mittal, S., Monteiro, R., Libbus, I., DiCarlo, L. A., Ardell, J. L., Amurthur, B., KenKnight, B. H., & Anand, I. S. (2021). Long-term Follow-Up of Patients with Heart Failure and Reduced Ejection Fraction Receiving Autonomic Regulation Therapy in the ANTHEM-HF Pilot Study. International Journal of Cardiology, 323, 175-178. https://doi.org/10.1016/j.ijcard.2020.09.072
Related studies in Heart Failure
Network meta-analysis on efficacy of nerve stimulation or modulation in patients with heart failure
Tseng et al. · Heart rhythm · 2026 · Systematic Review / Meta-Analysis
Complications of Implanted Vagus Nerve Stimulation: A Systematic Review and Meta-Analysis
Kalagara et al. · Cerebrovascular diseases (Basel, Switzerland) · 2025 · Systematic Review / Meta-Analysis
The efficacy of transcutaneous vagus nerve stimulation in heart failure management - a systematic review and meta-analysis
Sun et al. · BMC cardiovascular disorders · 2025 · Systematic Review / Meta-Analysis
Non-pharmacologic autonomic neuromodulation for treatment of heart failure: A systematic review and meta-analysis of randomized controlled trials
Ahmed et al. · Trends in cardiovascular medicine · 2024 · Systematic Review / Meta-Analysis
Summary by Vagus Research. Always consult the primary source for the authoritative record.