The Effect of Transcutaneous Trigeminal Nerve Stimulation and Transcutaneous Auricular Vagal Nerve Stimulation on the Biomarker Response to Stress
Roberts BM, Conn KM, Hildebrandt A, Connor KR, Lange E, Geddis AV, Taylor A, Ekon N, Heaton KJ, Ridgewell C, et al.
Neuromodulation: Technology at the Neural Interface · 2025
Key finding
The TSST induced a stress response by increasing levels of cortisol, DHEA-s, prolactin, IGF-I, and NE relative to baseline.
- Condition
- Stress & Performance
- Stimulation
- taVNS
- Evidence tier
- Controlled Clinical Trial
- Participants
- —
Cite this study
Roberts, B. M., Conn, K. M., Hildebrandt, A., Connor, K. R., Lange, E., Geddis, A. V., Taylor, A., Ekon, N., Heaton, K. J., Ridgewell, C., & Neumeier, W. H. (2025). The Effect of Transcutaneous Trigeminal Nerve Stimulation and Transcutaneous Auricular Vagal Nerve Stimulation on the Biomarker Response to Stress. Neuromodulation: Technology at the Neural Interface, 28(8), 1374-1383. https://doi.org/10.1016/j.neurom.2025.05.008
Related studies in Stress & Performance
Effects of Auricular Stimulation on Inflammatory Parameters: Results of a Systematic Review and Meta-Analysis of Randomized Controlled Trials
Hua et al. · Neuromodulation : journal of the International Neuromodulation Society · 2025 · Systematic Review / Meta-Analysis
Effects of taVNS on physiological responses and cognitive performance during a mental stressor
Drost et al. · Cognitive, Affective, & Behavioral Neuroscience · 2025 · Randomised Controlled Trial
Effects of cervical transcutaneous Vagus Nerve Stimulation (ctVNS) on military cognitive performance during sleep deprivation
Bottenheft et al. · Frontiers in Physiology · 2025 · Randomised Controlled Trial
Effects of multisession prefrontal cortex tDCS or taVNS on stress, perceived stress and sleep quality: a double-blind, randomized controlled study
dos Reis et al. · Frontiers in Psychology · 2024 · Randomised Controlled Trial
Summary by Vagus Research. Always consult the primary source for the authoritative record.