Effects of Transcutaneous Auricular Vagus Nerve Stimulation on Fatigue in Post-COVID Syndrome: A Randomized, Single-Blind, Sham-Controlled Study
Percin A, Ozden AV, Yenisehir S, Pehlivanoglu BE, Yılmaz RC
International Journal of Clinical Practice · 2025
Key finding
Both active and sham taVNS reduced post-COVID fatigue, with sham stimulation superior to active taVNS on fatigue severity — a negative result for taVNS.
- Condition
- Long COVID
- Stimulation
- taVNS
- Evidence tier
- Randomised Controlled Trial
- Participants
- 42
Cite this study
Percin, A., Ozden, A. V., Yenisehir, S., Pehlivanoglu, B. E., & Yılmaz, R. C. (2025). Effects of Transcutaneous Auricular Vagus Nerve Stimulation on Fatigue in Post-COVID Syndrome: A Randomized, Single-Blind, Sham-Controlled Study. International Journal of Clinical Practice, 2025(1). https://doi.org/10.1155/ijcp/5641307
Related studies in Long COVID
Transcutaneous Auricular Vagus Nerve Stimulation for Post-COVID-19 Condition: A Systematic Review and Critical Appraisal of Clinical Evidence
Balan et al. · Journal of Clinical Medicine · 2026 · Systematic Review / Meta-Analysis
Effects of Non-invasive Vagus Nerve Stimulation on Inflammatory Markers in COVID-19 Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Taha et al. · Cureus · 2024 · Systematic Review / Meta-Analysis
Effect of Percutaneous Auricular Nerve Stimulation on Fatigue in Adults with Post-COVID Fatigue (PAuSing-pCF): Results of a Randomised, Sham-Controlled Trial
Shahmandi et al. · NIHR Open Research · 2026 · Randomised Controlled Trial
Transcutaneous Auricular Vagal Nerve Stimulation Against Fatigue Syndrome in Patients with Long COVID: Results of the Randomized, Placebo-Controlled Clinical Pilot Trial COVIVA
Gierthmuehlen et al. · Neurology and Therapy · 2026 · Randomised Controlled Trial
Summary by Vagus Research. Always consult the primary source for the authoritative record.