Transauricular Vagus Nerve Stimulation (taVNS) enhances Conditioned Pain Modulation (CPM) in healthy subjects: A randomized controlled trial
Pacheco-Barrios K, Gianlorenco AC, Camargo L, Andrade MF, Choi H, Song JJ, Fregni F
Brain Stimulation · 2024
Key finding
In 44 healthy adults, active taVNS significantly enhanced conditioned pain modulation compared with sham, supporting an endogenous pain-inhibitory effect.
- Condition
- Pain
- Stimulation
- taVNS
- Evidence tier
- Randomised Controlled Trial
- Participants
- 44
Cite this study
Pacheco-Barrios, K., Gianlorenco, A. C., Camargo, L., Andrade, M. F., Choi, H., Song, J. J., & Fregni, F. (2024). Transauricular Vagus Nerve Stimulation (taVNS) enhances Conditioned Pain Modulation (CPM) in healthy subjects: A randomized controlled trial. Brain Stimulation, 17(2), 346-348. https://doi.org/10.1016/j.brs.2024.03.006
Related studies in Pain
The Effect of Vagus Nerve Stimulation on Pain Severity Scores in Patients With Chronic Musculoskeletal Pain Syndrome: A Meta-Analysis
Buchman et al. · Cureus · 2026 · Systematic Review / Meta-Analysis
International Headache society evidence-based guidelines on the use of non-invasive neuromodulation devices for the acute and preventive treatment of migraine
Yuan et al. · Cephalalgia : an international journal of headache · 2025 · Systematic Review / Meta-Analysis
Effects of transcutaneous vagus nerve stimulation on chronic low back pain: a systematic review
Eid et al. · BMC musculoskeletal disorders · 2024 · Systematic Review / Meta-Analysis
Electroencephalography Microstates Reveal Variability in Efficacy of Transcutaneous Auricular Vagus Nerve Stimulation in Primary Dysmenorrhea
Wang et al. · Annals of the New York Academy of Sciences · 2026 · Randomised Controlled Trial
Summary by Vagus Research. Always consult the primary source for the authoritative record.