Vagal nerve stimulation as a possible non-invasive treatment for chronic widespread pain in Gulf veterans with Gulf War Illness
Natelson BH, Stegner AJ, Lange G, Khan S, Blate M, Sotolongo A, DeLuca M, Van Doren WW, Helmer DA
Life Sciences · 2021
Key finding
Double-blind RCT in Gulf War Illness found non-invasive VNS produced NO improvement in widespread pain or migraine versus sham (null result).
- Condition
- Chronic Fatigue Syndrome
- Stimulation
- tcVNS
- Evidence tier
- Randomised Controlled Trial
- Participants
- 27
Cite this study
Natelson, B. H., Stegner, A. J., Lange, G., Khan, S., Blate, M., Sotolongo, A., DeLuca, M., Van Doren, W. W., & Helmer, D. A. (2021). Vagal nerve stimulation as a possible non-invasive treatment for chronic widespread pain in Gulf veterans with Gulf War Illness. Life Sciences, 282, 119805. https://doi.org/10.1016/j.lfs.2021.119805
Related studies in Chronic Fatigue Syndrome
Potential application of brain-gut axis-based treatments in Long COVID and ME/CFS: a case-based systematic review
Kim et al. · Journal of translational medicine · 2026 · Systematic Review / Meta-Analysis
Complementary and alternative medicine for long COVID: a systematic review of randomized controlled trials
Yang et al. · Therapeutic advances in chronic disease · 2023 · Systematic Review / Meta-Analysis
Evidence of bottom-up homeostatic modulation induced taVNS during emotional and Go/No-Go tasks
Camargo et al. · Experimental brain research · 2024 · Randomised Controlled Trial
The effects of non-invasive vagus nerve stimulation on fatigue in participants with primary Sjogren's syndrome
Tarn et al. · Neuromodulation · 2023 · Randomised Controlled Trial
Summary by Vagus Research. Always consult the primary source for the authoritative record.