Non-invasive vagus nerve stimulation for prevention of migraine: The multicenter, randomized, double-blind, sham-controlled PREMIUM II trial
Najib U, Smith T, Hindiyeh N, Saper J, Nye B, Ashina S, McClure CK, Marmura MJ, Chase S, Liebler E, et al.
Cephalalgia · 2022
Key finding
Active nVNS achieved a 44.87% responder rate versus 26.81% for sham (P=0.048), with migraine with aura patients showing a therapeutic gain exceeding 100% over sham.
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- Condition
- Migraine
- Stimulation
- iVNS
- Evidence tier
- Randomised Controlled Trial
- Participants
- 336
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Cite this study
Najib, U., Smith, T., Hindiyeh, N., Saper, J., Nye, B., Ashina, S., McClure, C. K., Marmura, M. J., Chase, S., Liebler, E., & Lipton, R. B. (2022). Non-invasive vagus nerve stimulation for prevention of migraine: The multicenter, randomized, double-blind, sham-controlled PREMIUM II trial. Cephalalgia, 42(7), 560-569. https://doi.org/10.1177/03331024211068813
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