Vagal Nerve Stimulation in Patients With Heart Failure and Reduced Ejection Fraction: The ANTHEM-HFrEF Trial
Konstam MA, Udelson JE, Mann DL, DiCarlo L, Butler J, Ardell J, De Ferrari GM, Klein HU, Filippatos G, Metra M, et al.
JACC · 2026
Key finding
In this prematurely terminated pivotal trial of 532 HFrEF patients, the underpowered primary endpoint of cardiovascular death or heart failure hospitalization was neutral, with safety and autonomic engagement demonstrated and only hypothesis-generating trends in symptoms and function.
- Condition
- Heart Failure
- Stimulation
- iVNS
- Evidence tier
- Randomised Controlled Trial
- Participants
- 532
Cite this study
Konstam, M. A., Udelson, J. E., Mann, D. L., DiCarlo, L., Butler, J., Ardell, J., De Ferrari, G. M., Klein, H. U., Filippatos, G., Metra, M., Anand, I., Close, N., Saville, B. R., Detry, M. A., Paulon, G., Khandwala, F., Bosse, A., KenKnight, B., Mindrebo, S., … Teerlink, J. R. (2026). Vagal Nerve Stimulation in Patients With Heart Failure and Reduced Ejection Fraction: The ANTHEM-HFrEF Trial. JACC, 87(25), 3490-3502. https://doi.org/10.1016/j.jacc.2026.03.040
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Summary by Vagus Research. Always consult the primary source for the authoritative record.