Vagal Nerve Stimulation in Patients With Heart Failure and Reduced Ejection Fraction: The ANTHEM-HFrEF Trial
Konstam MA, Udelson JE, Mann DL, DiCarlo L, Butler J, Ardell J, De Ferrari GM, Klein HU, Filippatos G, Metra M, et al.
JACC · 2026
Key finding
In the ANTHEM-HF-2 RCT (532 patients; enrollment terminated early), VNS did NOT meet its primary efficacy endpoint in heart failure with reduced ejection fraction, though device safety was high.
Auto-extracted · verification pendingHow we verify
- Condition
- Heart Failure
- Stimulation
- iVNS
- Evidence tier
- Randomised Controlled Trial
- Participants
- 532
Share this study
Download the citation card as a PNG, or copy a link to this page.
Cite this study
Konstam, M. A., Udelson, J. E., Mann, D. L., DiCarlo, L., Butler, J., Ardell, J., De Ferrari, G. M., Klein, H. U., Filippatos, G., Metra, M., Anand, I., Close, N., Saville, B. R., Detry, M. A., Paulon, G., Khandwala, F., Bosse, A., KenKnight, B., Mindrebo, S., … Teerlink, J. R. (2026). Vagal Nerve Stimulation in Patients With Heart Failure and Reduced Ejection Fraction: The ANTHEM-HFrEF Trial. JACC, 87(25), 3490-3502. https://doi.org/10.1016/j.jacc.2026.03.040
Related studies in Heart Failure
Network meta-analysis on efficacy of nerve stimulation or modulation in patients with heart failure
Tseng et al. · Heart rhythm · 2026 · Systematic Review / Meta-Analysis
The efficacy of transcutaneous vagus nerve stimulation in heart failure management - a systematic review and meta-analysis
Sun et al. · BMC cardiovascular disorders · 2025 · Systematic Review / Meta-Analysis
Non-pharmacologic autonomic neuromodulation for treatment of heart failure: A systematic review and meta-analysis of randomized controlled trials
Ahmed et al. · Trends in cardiovascular medicine · 2024 · Systematic Review / Meta-Analysis
Vagal Neuromodulation in Chronic Heart Failure With Reduced Ejection Fraction: A Systematic Review and Meta-Analysis
Sant'Anna et al. · Frontiers in Cardiovascular Medicine · 2021 · Systematic Review / Meta-Analysis
Summary by Vagus Research. Always consult the primary source for the authoritative record.