Noninvasive vagal nerve stimulation reduces withdrawal-related affective distress and improves functional outcomes in alcohol use disorder - A feasibility and acceptability pilot study
Klaming R, Harlé KM, Lerman IR, Norman SB, Strigo IA, Simmons AN, Spadoni AD
Neuromodulation: Technology at the Neural Interface · 2025
Key finding
Self-administered cervical nVNS was feasible and acceptable in Veterans with alcohol use disorder and reduced withdrawal-related affective distress with improved functional outcomes versus sham.
- Condition
- Addiction
- Stimulation
- tcVNS
- Evidence tier
- Controlled Clinical Trial
- Participants
- 19
Cite this study
Klaming, R., Harlé, K. M., Lerman, I. R., Norman, S. B., Strigo, I. A., Simmons, A. N., & Spadoni, A. D. (2025). Noninvasive vagal nerve stimulation reduces withdrawal-related affective distress and improves functional outcomes in alcohol use disorder - A feasibility and acceptability pilot study. Neuromodulation: Technology at the Neural Interface, 28(8), 1418-1428. https://doi.org/10.1016/j.neurom.2025.08.413
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