Transcutaneous cervical vagus nerve stimulation reduces behavioral and physiological manifestations of withdrawal in patients with opioid use disorder: A double-blind, randomized, sham-controlled pilot study
Gazi AH, Harrison AB, Lambert TP, Obideen M, Alavi P, Murrah N, Shallenberger L, Driggers EG, Ortega RA, Washington BP, et al.
Brain Stimulation · 2022
Key finding
Active tcVNS during opioid cue exposure significantly reduced subjective withdrawal, pain, distress, and heart rate versus sham, though craving did not differ significantly.
- Condition
- Addiction
- Stimulation
- tcVNS
- Evidence tier
- Randomised Controlled Trial
- Participants
- 21
Cite this study
Gazi, A. H., Harrison, A. B., Lambert, T. P., Obideen, M., Alavi, P., Murrah, N., Shallenberger, L., Driggers, E. G., Ortega, R. A., Washington, B. P., Walton, K. M., Welsh, J. W., Vaccarino, V., Shah, A. J., Tang, Y. L., Gupta, R., Back, S. E., Inan, O. T., & Bremner, J. D. (2022). Transcutaneous cervical vagus nerve stimulation reduces behavioral and physiological manifestations of withdrawal in patients with opioid use disorder: A double-blind, randomized, sham-controlled pilot study. Brain Stimulation, 15(5), 1206-1214. https://doi.org/10.1016/j.brs.2022.08.017
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Summary by Vagus Research. Always consult the primary source for the authoritative record.