Systematic review for VNS vs. pharmaceutical modulations for multifaceted neurological disorder management through cross-case, network meta-analysis
Han HJ, Kim H, Kim DJ
Brain Stimulation · 2025
Key finding
We included 56 VNS-related studies (n = 5773 participants) and 29 pharmacological drug-based studies (n = 14827 participants) from spanning epilepsy, depression, migraine/headache, Alzheimer's disease, inflammatory disorders, and heart failure.
- Condition
- Safety
- Stimulation
- taVNS
- Evidence tier
- Systematic Review / Meta-Analysis
- Participants
- 5,773
Cite this study
Han, H. J., Kim, H., & Kim, D. J. (2025). Systematic review for VNS vs. pharmaceutical modulations for multifaceted neurological disorder management through cross-case, network meta-analysis. Brain Stimulation, 18(3), 909-936. https://doi.org/10.1016/j.brs.2025.04.007
Related studies in Safety
The role of transcutaneous auricular vagus nerve stimulation in chronic pain: from neurobiological mechanisms to clinical applications
Zhang et al. · Frontiers in pain research (Lausanne, Switzerland) · 2026 · Systematic Review / Meta-Analysis
Transcutaneous auricular vagus nerve stimulation for postoperative pain: a protocol for a systematic review and meta-analysis
Lu et al. · BMJ open · 2026 · Systematic Review / Meta-Analysis
Efficacy of transcutaneous vagus nerve stimulation (t-VNS) in treating drug-resistant epilepsy: A systematic review and meta-analysis
Makkawi et al. · Epilepsy research · 2025 · Systematic Review / Meta-Analysis
Optimizing vagus nerve stimulation for Super Refractory Status Epilepticus: A case series and systematic review
Pichardo-Rojas et al. · Epileptic disorders : international epilepsy journal with videotape · 2025 · Systematic Review / Meta-Analysis
Summary by Vagus Research. Always consult the primary source for the authoritative record.