Vagus Nerve Stimulation for the Treatment of Heart Failure: The INOVATE-HF Trial
Gold MR, Van Veldhuisen DJ, Hauptman PJ, Borggrefe M, Kubo SH, Lieberman RA, Milasinovic G, Berman BJ, Djordjevic S, Neelagaru S, et al.
Journal of the American College of Cardiology · 2016
Key finding
VNS did not reduce the rate of death or heart failure events, though secondary endpoints (quality of life, NYHA class, 6-minute walk) improved, suggesting the need for optimised stimulation parameters.
- Condition
- Heart Failure
- Stimulation
- iVNS
- Evidence tier
- Randomised Controlled Trial
- Participants
- 707
Cite this study
Gold, M. R., Van Veldhuisen, D. J., Hauptman, P. J., Borggrefe, M., Kubo, S. H., Lieberman, R. A., Milasinovic, G., Berman, B. J., Djordjevic, S., Neelagaru, S., Schwartz, P. J., Starling, R. C., & Mann, D. L. (2016). Vagus Nerve Stimulation for the Treatment of Heart Failure: The INOVATE-HF Trial. Journal of the American College of Cardiology, 68(2), 149-158. https://doi.org/10.1016/j.jacc.2016.03.525
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Summary by Vagus Research. Always consult the primary source for the authoritative record.