Safety and efficacy of neurostimulation with a miniaturised vagus nerve stimulation device in patients with multidrug-refractory rheumatoid arthritis: a two-stage multicentre, randomised pilot study
Genovese MC, Gaylis NB, Sikes D, Kivitz A, Lewis Horowitz D, Peterfy C, Glass EV, Levine YA, Chernoff D
The Lancet Rheumatology · 2020
Key finding
A miniaturised implanted vagus nerve stimulation device (MicroRegulator) was safe and well tolerated and reduced signs and symptoms in patients with multidrug-refractory RA, with once-daily stimulation showing the greatest DAS28-CRP improvement.
- Condition
- Rheumatoid Arthritis
- Stimulation
- iVNS
- Evidence tier
- Controlled Clinical Trial
- Participants
- 14
Cite this study
Genovese, M. C., Gaylis, N. B., Sikes, D., Kivitz, A., Lewis Horowitz, D., Peterfy, C., Glass, E. V., Levine, Y. A., & Chernoff, D. (2020). Safety and efficacy of neurostimulation with a miniaturised vagus nerve stimulation device in patients with multidrug-refractory rheumatoid arthritis: a two-stage multicentre, randomised pilot study. The Lancet Rheumatology, 2(9), e527-e538. https://doi.org/10.1016/s2665-9913(20)30172-7
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Summary by Vagus Research. Always consult the primary source for the authoritative record.