Non-invasive vagus nerve stimulation (nVNS) for the preventive treatment of episodic migraine: The multicentre, double-blind, randomised, sham-controlled PREMIUM trial
Diener HC, Goadsby PJ, Ashina M, Al-Karagholi MAM, Sinclair A, Mitsikostas D, Magis D, Pozo-Rosich P, Irimia Sieira P, Làinez MJ, et al.
Cephalalgia · 2019
Key finding
Though the primary endpoint was not met, post hoc analysis of adherent patients showed significant benefit of nVNS for migraine prevention, with sham device inadvertently found to have parasympathetic activity.
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- Condition
- Migraine
- Stimulation
- tcVNS
- Evidence tier
- Randomised Controlled Trial
- Participants
- 477
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Cite this study
Diener, H. C., Goadsby, P. J., Ashina, M., Al-Karagholi, M. A. M., Sinclair, A., Mitsikostas, D., Magis, D., Pozo-Rosich, P., Irimia Sieira, P., Làinez, M. J., Gaul, C., Silver, N., Hoffmann, J., Marin, J., Liebler, E., & Ferrari, M. D. (2019). Non-invasive vagus nerve stimulation (nVNS) for the preventive treatment of episodic migraine: The multicentre, double-blind, randomised, sham-controlled PREMIUM trial. Cephalalgia, 39(12), 1475-1487. https://doi.org/10.1177/0333102419876920
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