Neuroimmune Modulation Through Vagus Nerve Stimulation Reduces Inflammatory Activity in Crohn's Disease Patients: A Prospective Open-label Study
D’Haens G, Eberhardson M, Cabrijan Z, Danese S, van den Berg R, Löwenberg M, Fiorino G, Schuurman PR, Lind G, Almqvist P, et al.
Journal of Crohn's and Colitis · 2023
Key finding
In a trial of 15 patients with Crohn's disease, VNS produced a clinically meaningful fall in disease-activity index and faecal calprotectin, with mucosal improvement in 11 of 15.
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- Condition
- Gut Health
- Stimulation
- iVNS
- Evidence tier
- Controlled Clinical Trial
- Participants
- 15
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Cite this study
D’Haens, G., Eberhardson, M., Cabrijan, Z., Danese, S., van den Berg, R., Löwenberg, M., Fiorino, G., Schuurman, P. R., Lind, G., Almqvist, P., Olofsson, P. S., Tracey, K. J., Hanauer, S. B., Zitnik, R., Chernoff, D., & Levine, Y. A. (2023). Neuroimmune Modulation Through Vagus Nerve Stimulation Reduces Inflammatory Activity in Crohn's Disease Patients: A Prospective Open-label Study. Journal of Crohn's and Colitis, 17(12), 1897-1909. https://doi.org/10.1093/ecco-jcc/jjad151
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