Neuroimmune Modulation Through Vagus Nerve Stimulation Reduces Inflammatory Activity in Crohn's Disease Patients: A Prospective Open-label Study
D’Haens G, Eberhardson M, Cabrijan Z, Danese S, van den Berg R, Löwenberg M, Fiorino G, Schuurman PR, Lind G, Almqvist P, et al.
Journal of Crohn's and Colitis · 2023
Key finding
There was a statistically significant and clinically meaningful decrease in CD Activity Index at Week 16 [mean ± SD: -86.2 ± 92.8, p = 0.003], a significant decrease in faecal calprotectin [-2923 ± 4104, p = 0.015], a decrease in mucosal inflammation in 11/15 patients with paired endoscopies [-2....
- Condition
- Gut Health
- Stimulation
- iVNS
- Evidence tier
- Controlled Clinical Trial
- Participants
- 15
Cite this study
D’Haens, G., Eberhardson, M., Cabrijan, Z., Danese, S., van den Berg, R., Löwenberg, M., Fiorino, G., Schuurman, P. R., Lind, G., Almqvist, P., Olofsson, P. S., Tracey, K. J., Hanauer, S. B., Zitnik, R., Chernoff, D., & Levine, Y. A. (2023). Neuroimmune Modulation Through Vagus Nerve Stimulation Reduces Inflammatory Activity in Crohn's Disease Patients: A Prospective Open-label Study. Journal of Crohn's and Colitis, 17(12), 1897-1909. https://doi.org/10.1093/ecco-jcc/jjad151
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Summary by Vagus Research. Always consult the primary source for the authoritative record.