Transcutaneous Auricular Vagus Nerve Stimulation Improves Inflammation but Does Not Interfere with Cardiac Modulation and Clinical Symptoms of Individuals with COVID-19: A Randomized Clinical Trial
Corrêa FI, Souza PHL, Uehara L, Ritti-Dias RM, Oliveira da Silva G, Segheto W, Pacheco-Barrios K, Fregni F, Corrêa JCF
Life · 2022
Key finding
Results: There was significant reduction in CRP −23.9%, (95% CI −46.3 to −1.4) and IL-6 −37.7%, (95% CI −57.6 to −17.7) for the a-taVNS group.
- Condition
- Long COVID
- Stimulation
- taVNS
- Evidence tier
- Randomised Controlled Trial
- Participants
- —
Cite this study
Corrêa, F. I., Souza, P. H. L., Uehara, L., Ritti-Dias, R. M., Oliveira da Silva, G., Segheto, W., Pacheco-Barrios, K., Fregni, F., & Corrêa, J. C. F. (2022). Transcutaneous Auricular Vagus Nerve Stimulation Improves Inflammation but Does Not Interfere with Cardiac Modulation and Clinical Symptoms of Individuals with COVID-19: A Randomized Clinical Trial. Life, 12(10), 1644. https://doi.org/10.3390/life12101644
Related studies in Long COVID
Transcutaneous Auricular Vagus Nerve Stimulation for Post-COVID-19 Condition: A Systematic Review and Critical Appraisal of Clinical Evidence
Balan et al. · Journal of Clinical Medicine · 2026 · Systematic Review / Meta-Analysis
Effects of Non-invasive Vagus Nerve Stimulation on Inflammatory Markers in COVID-19 Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Taha et al. · Cureus · 2024 · Systematic Review / Meta-Analysis
Effect of Percutaneous Auricular Nerve Stimulation on Fatigue in Adults with Post-COVID Fatigue (PAuSing-pCF): Results of a Randomised, Sham-Controlled Trial
Shahmandi et al. · NIHR Open Research · 2026 · Randomised Controlled Trial
Transcutaneous Auricular Vagal Nerve Stimulation Against Fatigue Syndrome in Patients with Long COVID: Results of the Randomized, Placebo-Controlled Clinical Pilot Trial COVIVA
Gierthmuehlen et al. · Neurology and Therapy · 2026 · Randomised Controlled Trial
Summary by Vagus Research. Always consult the primary source for the authoritative record.