Optimizing transcutaneous vagus nerve stimulation parameters for sleep and autonomic function in veterans with posttraumatic stress disorder with or without mild traumatic brain injury
Bottari SA, Trifilio ER, Rohl B, Wu SS, Miller-Sellers D, Waldorff I, Hadigal S, Jaffee MS, Ferri R, Lamb DG, et al.
SLEEP · 2025
Key finding
The parameter combination of 20Hz, 100μs pulse width, and 80% discomfort threshold was associated with the most optimal outcomes across both intent-to-treat and per protocol analyses.
- Condition
- Anxiety
- Stimulation
- taVNS
- Evidence tier
- Controlled Clinical Trial
- Participants
- —
Cite this study
Bottari, S. A., Trifilio, E. R., Rohl, B., Wu, S. S., Miller-Sellers, D., Waldorff, I., Hadigal, S., Jaffee, M. S., Ferri, R., Lamb, D. G., Porges, E. C., & Williamson, J. B. (2025). Optimizing transcutaneous vagus nerve stimulation parameters for sleep and autonomic function in veterans with posttraumatic stress disorder with or without mild traumatic brain injury. SLEEP, 48(8). https://doi.org/10.1093/sleep/zsaf152
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Summary by Vagus Research. Always consult the primary source for the authoritative record.