Gut-brain communication by distinct sensory neurons differently controls feeding and glucose metabolism
Borgmann D, Ciglieri E, Biglari N, Brandt C, Cremer AL, Backes H, Tittgemeyer M, Wunderlich FT, Brüning JC, Fenselau H
Cell Metabolism · 2021
Key finding
Bidirectional chemogenetic manipulations, coupled with behavioral and circuit mapping analysis, demonstrated that gut-innervating, glucagon-like peptide 1 receptor (GLP1R)-expressing vagal afferents relay anorexigenic signals to parabrachial nucleus neurons that control meal termination.
- Condition
- Metabolic
- Stimulation
- taVNS
- Evidence tier
- Controlled Clinical Trial
- Participants
- —
Cite this study
Borgmann, D., Ciglieri, E., Biglari, N., Brandt, C., Cremer, A. L., Backes, H., Tittgemeyer, M., Wunderlich, F. T., Brüning, J. C., & Fenselau, H. (2021). Gut-brain communication by distinct sensory neurons differently controls feeding and glucose metabolism. Cell Metabolism, 33(7), 1466-1482.e7. https://doi.org/10.1016/j.cmet.2021.05.002
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Summary by Vagus Research. Always consult the primary source for the authoritative record.