Safety and preliminary efficacy of transcutaneous auricular vagus nerve stimulation on chronic knee pain: A pilot trial
Aoyagi K, Rivas E, Shababi R, Edwards R, LaValley M, Lechuga J, Napadow V, Neogi T
Osteoarthritis and Cartilage Open · 2025
Key finding
In a 30-patient knee osteoarthritis pilot, a single 60-min taVNS session reduced knee pain and improved conditioned pain modulation, though pressure pain threshold and temporal summation were unchanged.
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- Condition
- Pain
- Stimulation
- taVNS
- Evidence tier
- Controlled Clinical Trial
- Participants
- 30
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Cite this study
Aoyagi, K., Rivas, E., Shababi, R., Edwards, R., LaValley, M., Lechuga, J., Napadow, V., & Neogi, T. (2025). Safety and preliminary efficacy of transcutaneous auricular vagus nerve stimulation on chronic knee pain: A pilot trial. Osteoarthritis and Cartilage Open, 7(1), 100545. https://doi.org/10.1016/j.ocarto.2024.100545
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