Efficacy and safety of transcutaneous auricular vagus nerve stimulation plus pregabalin for radiotherapy-related neuropathic pain in patients with head and neck cancer (RELAX): a phase 2 randomised trial
Zuo X, Xu Y, Li S, Jiang J, Wang J, Zhu Y, Pan D, Li H, Chen Y, Chen Y, et al.
eClinicalMedicine · 2025
Key finding
Between September 16, 2022, and December 1, 2023, 116 eligible patients (mean age, 50.8 [standard deviation (SD), 8.8] years; 40 [34.5%] were women) were randomly assigned into groups.
Auto-extracted · verification pendingHow we verify
- Condition
- Cancer Support
- Stimulation
- taVNS
- Evidence tier
- Randomised Controlled Trial
- Participants
- —
Share this study
Download the citation card as a PNG, or copy a link to this page.
Cite this study
Zuo, X., Xu, Y., Li, S., Jiang, J., Wang, J., Zhu, Y., Pan, D., Li, H., Chen, Y., Chen, Y., Rong, X., Zheng, D., Lu, K., Mai, H., Chen, M., Chen, P., Li, J., Simone, C. B., Chua, M. L. K., … Tang, Y. (2025). Efficacy and safety of transcutaneous auricular vagus nerve stimulation plus pregabalin for radiotherapy-related neuropathic pain in patients with head and neck cancer (RELAX): a phase 2 randomised trial. eClinicalMedicine, 86, 103345. https://doi.org/10.1016/j.eclinm.2025.103345
Related studies in Cancer Support
Vagus Nerve Stimulation for Tumor-Related Epilepsy: Does It Make Sense?
Lam et al. · The Permanente journal · 2021 · Controlled Clinical Trial
Hydrogel-based electrodes for selective cervical vagus nerve stimulation
Horn et al. · Journal of neural engineering · 2021 · Controlled Clinical Trial
Vagus nerve stimulation dampens intestinal inflammation in a murine model of experimental food allergy
Bosmans et al. · Allergy · 2019 · Controlled Clinical Trial
Putative role of non-invasive vagus nerve stimulation in cancer pathology and immunotherapy: Can this be a hidden treasure, especially for the elderly?
Abdullahi et al. · Cancer medicine · 2023 · Narrative / Scoping Review
Summary by Vagus Research. Always consult the primary source for the authoritative record.