Efficacy and safety of transcutaneous auricular vagus nerve stimulation plus pregabalin for radiotherapy-related neuropathic pain in patients with head and neck cancer (RELAX): a phase 2 randomised trial
Zuo X, Xu Y, Li S, Jiang J, Wang J, Zhu Y, Pan D, Li H, Chen Y, Chen Y, et al.
eClinicalMedicine · 2025
Key finding
Between September 16, 2022, and December 1, 2023, 116 eligible patients (mean age, 50.8 [standard deviation (SD), 8.8] years; 40 [34.5%] were women) were randomly assigned into groups.
- Condition
- Cancer Support
- Stimulation
- taVNS
- Evidence tier
- Randomised Controlled Trial
- Participants
- —
Cite this study
Zuo, X., Xu, Y., Li, S., Jiang, J., Wang, J., Zhu, Y., Pan, D., Li, H., Chen, Y., Chen, Y., Rong, X., Zheng, D., Lu, K., Mai, H., Chen, M., Chen, P., Li, J., Simone, C. B., Chua, M. L. K., … Tang, Y. (2025). Efficacy and safety of transcutaneous auricular vagus nerve stimulation plus pregabalin for radiotherapy-related neuropathic pain in patients with head and neck cancer (RELAX): a phase 2 randomised trial. eClinicalMedicine, 86, 103345. https://doi.org/10.1016/j.eclinm.2025.103345
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Summary by Vagus Research. Always consult the primary source for the authoritative record.