An individual patient data meta-analysis on vagal nerve stimulation for recovery from disorders of consciousness
Zhang JJ, Lo YT, Wee AXQ, Yeo J, Suan E, Zhang Z, Lim MJR, Chua KSG
Scientific Reports · 2026
Key finding
Pooling individual data from 10 studies (112 patients), VNS was associated with a mean CRS-R increase of 2.78 points, with 40.2% exceeding the minimal clinically important difference and greater gains in minimally conscious state patients.
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- Condition
- Disorders of Consciousness
- Stimulation
- taVNS
- Evidence tier
- Systematic Review / Meta-Analysis
- Participants
- 112
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Cite this study
Zhang, J. J., Lo, Y. T., Wee, A. X. Q., Yeo, J., Suan, E., Zhang, Z., Lim, M. J. R., & Chua, K. S. G. (2026). An individual patient data meta-analysis on vagal nerve stimulation for recovery from disorders of consciousness. Scientific Reports, 16(1). https://doi.org/10.1038/s41598-025-32369-0
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