Randomised Controlled TrialtcVNSn = 22

Noninvasive Cervical Vagal Nerve Stimulation Alters Brain Activity During Traumatic Stress in Individuals With Posttraumatic Stress Disorder

Wittbrodt M, Gurel N, Nye J, Shandhi M, Gazi A, Shah A, Pearce B, Murrah N, Ko Y, Shallenberger L, et al.

Psychosomatic Medicine · 2021

Key finding

In an RCT, tcVNS altered brain activity during traumatic-memory scripts — increasing frontal, temporal, hippocampal and cingulate activation — versus sham in trauma-exposed individuals.

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Condition
PTSD
Stimulation
tcVNS
Evidence tier
Randomised Controlled Trial
Participants
22
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Cite this study

Wittbrodt, M., Gurel, N., Nye, J., Shandhi, M., Gazi, A., Shah, A., Pearce, B., Murrah, N., Ko, Y., Shallenberger, L., Vaccarino, V., Inan, O., & Bremner, J. (2021). Noninvasive Cervical Vagal Nerve Stimulation Alters Brain Activity During Traumatic Stress in Individuals With Posttraumatic Stress Disorder. Psychosomatic Medicine.

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