Vagus nerve stimulation inhibits pyroptosis and improves outcome of cerebral ischemic stroke by upregulating osteopontin (SPP1) to disturb ASC oligomerization
Wen J, Tang H, Wang L, Yang Q, Zhao Y, Ren Y, Qin T, Li X, Xu J, Jia G, et al.
BMC Medicine · 2025
Key finding
In MCAO/R rats and AIS patients, osteopontin levels were elevated.
- Condition
- Stroke Rehabilitation
- Stimulation
- iVNS
- Evidence tier
- Randomised Controlled Trial
- Participants
- —
Cite this study
Wen, J., Tang, H., Wang, L., Yang, Q., Zhao, Y., Ren, Y., Qin, T., Li, X., Xu, J., Jia, G., & Yang, Q. (2025). Vagus nerve stimulation inhibits pyroptosis and improves outcome of cerebral ischemic stroke by upregulating osteopontin (SPP1) to disturb ASC oligomerization. BMC Medicine, 23(1). https://doi.org/10.1186/s12916-025-04242-4
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