Vagus Nerve Stimulation Paired with Tones for the Treatment of Tinnitus: A Prospective Randomized Double-blind Controlled Pilot Study in Humans
Tyler R, Cacace A, Stocking C, Tarver B, Engineer N, Martin J, Deshpande A, Stecker N, Pereira M, Kilgard M, et al.
Scientific Reports · 2017
Key finding
After 6 weeks, 50% of participants in the VNS-paired-tones group showed clinically meaningful THI improvements versus 28% of controls, with benefits sustained at one year.
Auto-extracted · verification pendingHow we verify
- Condition
- Tinnitus
- Stimulation
- iVNS
- Evidence tier
- Randomised Controlled Trial
- Participants
- 30
Share this study
Download the citation card as a PNG, or copy a link to this page.
Cite this study
Tyler, R., Cacace, A., Stocking, C., Tarver, B., Engineer, N., Martin, J., Deshpande, A., Stecker, N., Pereira, M., Kilgard, M., Burress, C., Pierce, D., Rennaker, R., & Vanneste, S. (2017). Vagus Nerve Stimulation Paired with Tones for the Treatment of Tinnitus: A Prospective Randomized Double-blind Controlled Pilot Study in Humans. Scientific Reports, 7(1). https://doi.org/10.1038/s41598-017-12178-w
Related studies in Tinnitus
Effects of Non-Invasive Neuromodulation of the Vagus Nerve for Management of Tinnitus: A Systematic Review with Meta-Analysis
Fernández-Hernando et al. · Journal of clinical medicine · 2023 · Systematic Review / Meta-Analysis
Tinnitus treatment by vagus nerve stimulation: A systematic review
Stegeman et al. · PloS one · 2021 · Systematic Review / Meta-Analysis
Meniere Disease treated with transcutaneous auricular vagus nerve stimulation combined with betahistine Mesylate: A randomized controlled trial
Wu et al. · Brain stimulation · 2023 · Randomised Controlled Trial
Pilot evaluation of transcutaneous vagus nerve stimulation in chronic tinnitus: clinical outcomes and DTI insights
Gedik Toker et al. · European Archives of Oto-Rhino-Laryngology · 2026 · Controlled Clinical Trial
Summary by Vagus Research. Always consult the primary source for the authoritative record.