Randomised Controlled TrialtcVNSn = 40

The effects of non-invasive vagus nerve stimulation on fatigue in participants with primary Sjogren's syndrome

Tarn J, Evans E, Traianos E, Collins A, Stylianou M, Parikh J, Bai Y, Guan Y, Frith J, Lendrem D, et al.

Neuromodulation · 2023

Key finding

Small double-blind RCT in Sjogren's syndrome found active non-invasive VNS improved several fatigue measures versus sham (fatigue in an autoimmune disease, not ME/CFS).

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Condition
Chronic Fatigue Syndrome
Stimulation
tcVNS
Evidence tier
Randomised Controlled Trial
Participants
40
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Cite this study

Tarn, J., Evans, E., Traianos, E., Collins, A., Stylianou, M., Parikh, J., Bai, Y., Guan, Y., Frith, J., Lendrem, D., Macrae, V., McKinnon, I., Simon, B., Blake, J., Baker, M., Taylor, J., Watson, S., Gallagher, P., Blamire, A., … Ng, W. (2023). The effects of non-invasive vagus nerve stimulation on fatigue in participants with primary Sjogren's syndrome. Neuromodulation.

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