Cognition-enhancing effect of vagus nerve stimulation in patients with Alzheimer's disease: a pilot study
Sjogren MJC, Hellstrom PTO, Jonsson MAG, Runnerstam M, C-son Silander H, Ben-Menachem E, Sjögren JC, Hellström PTO
The Journal of Clinical Psychiatry · 2002
Key finding
After 3 months of treatment, 7 of 10 patients were responders according to the ADAS-cog (median improvement of 3.0 points), and 9 of 10 patients were responders according to the MMSE (median improvement of 1.5 points).
- Condition
- Alzheimer's Disease
- Stimulation
- iVNS
- Evidence tier
- Controlled Clinical Trial
- Participants
- 10
Cite this study
Sjogren, M. J. C., Hellstrom, P. T. O., Jonsson, M. A. G., Runnerstam, M., C-son Silander, H., Ben-Menachem, E., Sjögren, J. C., & Hellström, P. T. O. (2002). Cognition-enhancing effect of vagus nerve stimulation in patients with Alzheimer's disease: a pilot study. The Journal of Clinical Psychiatry, 63(11), 972-980. https://doi.org/10.4088/jcp.v63n1103
Related studies in Alzheimer's Disease
Advances in VNS efficiency and mechanisms of action on cognitive functions
Wang et al. · Frontiers in physiology · 2024 · Systematic Review / Meta-Analysis
Locus coeruleus fMRI response to transcutaneous auricular vagus nerve stimulation is coupled to changes in salivary alpha amylase
Schneider et al. · Brain stimulation · 2025 · Controlled Clinical Trial
A vagal route to memory: evidence from invasive and non-invasive electrical vagus nerve stimulation studies and areas for future clinical application
Szeska et al. · Frontiers in human neuroscience · 2025 · Controlled Clinical Trial
Vagus Nerve Stimulation for Improvement of Vascular Cognitive Impairment
E et al. · Neuropsychiatric disease and treatment · 2024 · Controlled Clinical Trial
Summary by Vagus Research. Always consult the primary source for the authoritative record.