Non-Invasive Vagus Nerve Stimulation for the ACute Treatment of Cluster Headache: Findings From the Randomized, Double-Blind, Sham-Controlled ACT1 Study
Silberstein SD, Mechtler LL, Kudrow DB, Calhoun AH, McClure C, Saper JR, Liebler EJ, Rubenstein Engel E, Tepper SJ
Headache: The Journal of Head and Face Pain · 2016
Key finding
In the ACT1 RCT (133 patients), non-invasive VNS relieved acute cluster-headache attacks more than sham in episodic (34% vs 11%) but not chronic cluster headache.
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- Condition
- Cluster Headache
- Stimulation
- tcVNS
- Evidence tier
- Randomised Controlled Trial
- Participants
- 150
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Cite this study
Silberstein, S. D., Mechtler, L. L., Kudrow, D. B., Calhoun, A. H., McClure, C., Saper, J. R., Liebler, E. J., Rubenstein Engel, E., & Tepper, S. J. (2016). Non-Invasive Vagus Nerve Stimulation for the ACute Treatment of Cluster Headache: Findings From the Randomized, Double-Blind, Sham-Controlled ACT1 Study. Headache: The Journal of Head and Face Pain, 56(8), 1317-1332. https://doi.org/10.1111/head.12896
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