Feasibility, safety and efficacy of multi-dose vagus nerve stimulation in Parkinson's disease: a double-blind, randomised sham-controlled proof-of-concept study
Sigurdsson HP, Hunter H, Alcock L, Maughan EE, Bramley H, Brown P, Palermo G, Baker MR, Taylor JP, Rochester L, et al.
Journal of Neurology · 2025
Key finding
Multi-dose cervical tcVNS was safe and tolerable but had minimal, non-significant effects on gait and cognition versus sham.
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- Condition
- Parkinson's Disease
- Stimulation
- tcVNS
- Evidence tier
- Randomised Controlled Trial
- Participants
- 33
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Cite this study
Sigurdsson, H. P., Hunter, H., Alcock, L., Maughan, E. E., Bramley, H., Brown, P., Palermo, G., Baker, M. R., Taylor, J. P., Rochester, L., & Yarnall, A. J. (2025). Feasibility, safety and efficacy of multi-dose vagus nerve stimulation in Parkinson's disease: a double-blind, randomised sham-controlled proof-of-concept study. Journal of Neurology, 272(10). https://doi.org/10.1007/s00415-025-13430-4
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