Sustained Weight Loss with Vagal Nerve Blockade but Not with Sham: 18-Month Results of the ReCharge Trial
Shikora SA, Wolfe BM, Apovian CM, Anvari M, Sarwer DB, Gibbons RD, Ikramuddin S, Miller CJ, Knudson MB, Tweden KS, et al.
Journal of Obesity · 2015
Key finding
Weight loss with vagal nerve blockade was sustained through 18 months whereas sham participants regained weight between 12 and 18 months, with a low rate of serious adverse events.
- Condition
- Obesity
- Stimulation
- iVNS
- Evidence tier
- Randomised Controlled Trial
- Participants
- 239
Cite this study
Shikora, S. A., Wolfe, B. M., Apovian, C. M., Anvari, M., Sarwer, D. B., Gibbons, R. D., Ikramuddin, S., Miller, C. J., Knudson, M. B., Tweden, K. S., Sarr, M. G., & Billington, C. J. (2015). Sustained Weight Loss with Vagal Nerve Blockade but Not with Sham: 18-Month Results of the ReCharge Trial. Journal of Obesity, 2015, 1-8. https://doi.org/10.1155/2015/365604
Related studies in Obesity
Effect of vagus nerve stimulation on metabolism: a systematic review and meta-analysis
Shen et al. · International journal of obesity (2005) · 2025 · Systematic Review / Meta-Analysis
Effects of auricular stimulation on weight- and obesity-related parameters: a systematic review and meta-analysis of randomized controlled clinical trials
Hua et al. · Frontiers in neuroscience · 2024 · Systematic Review / Meta-Analysis
Neuromodulation for the treatment of Prader-Willi syndrome - A systematic review
Qiu et al. · Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2024 · Systematic Review / Meta-Analysis
Vagal Nerve Therapy in the Management of Obesity: A Systematic Review and Meta-Analysis
Fadel et al. · European Surgical Research · 2023 · Systematic Review / Meta-Analysis
Summary by Vagus Research. Always consult the primary source for the authoritative record.