Novel insights into maladaptive behaviours in Prader-Willi syndrome: serendipitous findings from an open trial of vagus nerve stimulation
Manning KE, McAllister CJ, Ring HA, Finer N, Kelly CL, Sylvester KP, Fletcher PC, Morrell NW, Garnett MR, Manford MRA, et al.
Journal of Intellectual Disability Research · 2016
Key finding
In three adults with PWS given implanted VNS, effects on hyperphagia were equivocal while two of three showed consistent improvement in maladaptive behaviour and temper outbursts.
- Condition
- Prader-Willi Syndrome
- Stimulation
- iVNS
- Evidence tier
- Controlled Clinical Trial
- Participants
- 3
Cite this study
Manning, K. E., McAllister, C. J., Ring, H. A., Finer, N., Kelly, C. L., Sylvester, K. P., Fletcher, P. C., Morrell, N. W., Garnett, M. R., Manford, M. R. A., & Holland, A. J. (2016). Novel insights into maladaptive behaviours in Prader-Willi syndrome: serendipitous findings from an open trial of vagus nerve stimulation. Journal of Intellectual Disability Research, 60(2), 149-155. https://doi.org/10.1111/jir.12203
Related studies in Prader-Willi Syndrome
Effects of long-term transcutaneous auricular vagus nerve stimulation on circadian vagal activity in people with Prader-Willi Syndrome: A case-series
Schmausser et al. · Research in Developmental Disabilities · 2024 · Controlled Clinical Trial
Transcutaneous vagus nerve stimulation (t-VNS): A novel effective treatment for temper outbursts in adults with Prader-Willi Syndrome indicated by results from a non-blind study
Manning et al. · PLoS One · 2019 · Controlled Clinical Trial
Summary by Vagus Research. Always consult the primary source for the authoritative record.